Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice
Identifieur interne : 002451 ( Main/Corpus ); précédent : 002450; suivant : 002452Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice
Auteurs : Dean E. DluzenSource :
- Brain Research [ 0006-8993 ] ; 1995.
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Abstract
We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). In the present report we examined whether the predominantly male gonadal steroid hormone, testosterone, would similarly modulate MPTP-induced neurotoxicity. Male C57/B1 mice were assigned to one of the following five treatment conditions: (1) Intact, (2) Orchidectomized, (3) Intact + MPTP, (4) Orchidectomized + Testosterone + MPTP and (5) Orchidectomized + MPTP. Corpus striatal and olfactory tubercle dopamine, DOP AC and norepinephrine concentrations were determined from the animals within each of the five treatment conditions. Orchidectomy alone failed to alter striatal dopamine and DOPAC concentrations, with levels obtained being similar to that of Intact animals. MPTP treatment significantly reduced striatal dopamine and DOPAC concentrations, regardless of hormonal condition of the animal. Similar results were obtained for olfactory tubercle determinations, with the exception that DOPAC levels from Orchidectomized mice were significantly greater than Intact males. No significant differences were obtained for norepinephrine within either brain area sampled. These results show that unlike estrogen, testosterone is devoid of any capacity to modulate nigrostriatal dopaminergic neurotoxicity resulting from MPTP. These findings may be related to the gender differences which exist in the prevalence of Parkinson's disease.
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DOI: 10.1016/0006-8993(95)01566-3
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice</title><author><name sortKey="Dluzen, Dean E" sort="Dluzen, Dean E" uniqKey="Dluzen D" first="Dean E." last="Dluzen">Dean E. Dluzen</name><affiliation><mods:affiliation>Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P.O. Box 95, Rootstown, OH 44272-0095, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:283969BD863F7C1F733916479DA0E5850489CDA3</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1016/0006-8993(95)01566-3</idno><idno type="url">https://api.istex.fr/document/283969BD863F7C1F733916479DA0E5850489CDA3/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002451</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice</title><author><name sortKey="Dluzen, Dean E" sort="Dluzen, Dean E" uniqKey="Dluzen D" first="Dean E." last="Dluzen">Dean E. Dluzen</name><affiliation><mods:affiliation>Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P.O. Box 95, Rootstown, OH 44272-0095, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">715</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="113">113</biblScope><biblScope unit="page" to="118">118</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">283969BD863F7C1F733916479DA0E5850489CDA3</idno><idno type="DOI">10.1016/0006-8993(95)01566-3</idno><idno type="PII">0006-8993(95)01566-3</idno><idno type="ArticleID">95015663</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Corpus striatum</term><term>Estrogen</term><term>Olfactory tubercle</term><term>Orchidectomy</term><term>Parkinson's disease</term><term>Sex differences</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). In the present report we examined whether the predominantly male gonadal steroid hormone, testosterone, would similarly modulate MPTP-induced neurotoxicity. Male C57/B1 mice were assigned to one of the following five treatment conditions: (1) Intact, (2) Orchidectomized, (3) Intact + MPTP, (4) Orchidectomized + Testosterone + MPTP and (5) Orchidectomized + MPTP. Corpus striatal and olfactory tubercle dopamine, DOP AC and norepinephrine concentrations were determined from the animals within each of the five treatment conditions. Orchidectomy alone failed to alter striatal dopamine and DOPAC concentrations, with levels obtained being similar to that of Intact animals. MPTP treatment significantly reduced striatal dopamine and DOPAC concentrations, regardless of hormonal condition of the animal. Similar results were obtained for olfactory tubercle determinations, with the exception that DOPAC levels from Orchidectomized mice were significantly greater than Intact males. No significant differences were obtained for norepinephrine within either brain area sampled. These results show that unlike estrogen, testosterone is devoid of any capacity to modulate nigrostriatal dopaminergic neurotoxicity resulting from MPTP. These findings may be related to the gender differences which exist in the prevalence of Parkinson's disease.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Dean E. Dluzen</name><affiliations><json:string>Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P.O. Box 95, Rootstown, OH 44272-0095, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Corpus striatum</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Olfactory tubercle</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Sex differences</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Orchidectomy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Estrogen</value></json:item></subject><articleId><json:string>95015663</json:string></articleId><language><json:string>eng</json:string></language><abstract>We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). In the present report we examined whether the predominantly male gonadal steroid hormone, testosterone, would similarly modulate MPTP-induced neurotoxicity. Male C57/B1 mice were assigned to one of the following five treatment conditions: (1) Intact, (2) Orchidectomized, (3) Intact + MPTP, (4) Orchidectomized + Testosterone + MPTP and (5) Orchidectomized + MPTP. Corpus striatal and olfactory tubercle dopamine, DOP AC and norepinephrine concentrations were determined from the animals within each of the five treatment conditions. Orchidectomy alone failed to alter striatal dopamine and DOPAC concentrations, with levels obtained being similar to that of Intact animals. MPTP treatment significantly reduced striatal dopamine and DOPAC concentrations, regardless of hormonal condition of the animal. Similar results were obtained for olfactory tubercle determinations, with the exception that DOPAC levels from Orchidectomized mice were significantly greater than Intact males. No significant differences were obtained for norepinephrine within either brain area sampled. These results show that unlike estrogen, testosterone is devoid of any capacity to modulate nigrostriatal dopaminergic neurotoxicity resulting from MPTP. These findings may be related to the gender differences which exist in the prevalence of Parkinson's disease.</abstract><qualityIndicators><score>5.95</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1623</abstractCharCount><pdfWordCount>3382</pdfWordCount><pdfCharCount>22802</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>214</abstractWordCount></qualityIndicators><title>Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice</title><pii><json:string>0006-8993(95)01566-3</json:string></pii><genre><json:string>research-article</json:string></genre><serie><volume>153</volume><pages><last>155</last><first>145</first></pages><genre></genre><language><json:string>unknown</json:string></language><title>Ciba Found. 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Fax: (1) (216) 325-2524.</p></note><affiliation>Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P.O. Box 95, Rootstown, OH 44272-0095, USA</affiliation></author></analytic><monogr><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="pISSN">0006-8993</idno><idno type="PII">S0006-8993(00)X1716-7</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995"></date><biblScope unit="volume">715</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="113">113</biblScope><biblScope unit="page" to="118">118</biblScope></imprint></monogr><idno type="istex">283969BD863F7C1F733916479DA0E5850489CDA3</idno><idno type="DOI">10.1016/0006-8993(95)01566-3</idno><idno type="PII">0006-8993(95)01566-3</idno><idno type="ArticleID">95015663</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). In the present report we examined whether the predominantly male gonadal steroid hormone, testosterone, would similarly modulate MPTP-induced neurotoxicity. Male C57/B1 mice were assigned to one of the following five treatment conditions: (1) Intact, (2) Orchidectomized, (3) Intact + MPTP, (4) Orchidectomized + Testosterone + MPTP and (5) Orchidectomized + MPTP. Corpus striatal and olfactory tubercle dopamine, DOP AC and norepinephrine concentrations were determined from the animals within each of the five treatment conditions. Orchidectomy alone failed to alter striatal dopamine and DOPAC concentrations, with levels obtained being similar to that of Intact animals. MPTP treatment significantly reduced striatal dopamine and DOPAC concentrations, regardless of hormonal condition of the animal. Similar results were obtained for olfactory tubercle determinations, with the exception that DOPAC levels from Orchidectomized mice were significantly greater than Intact males. No significant differences were obtained for norepinephrine within either brain area sampled. These results show that unlike estrogen, testosterone is devoid of any capacity to modulate nigrostriatal dopaminergic neurotoxicity resulting from MPTP. These findings may be related to the gender differences which exist in the prevalence of Parkinson's disease.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Corpus striatum</term></item><item><term>Olfactory tubercle</term></item><item><term>Parkinson's disease</term></item><item><term>Sex differences</term></item><item><term>Orchidectomy</term></item><item><term>Estrogen</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1995-12-12">Registration</change><change when="1995">Published</change></revisionDesc></teiHeader></istex:fulltextTEI></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>BRES</jid><aid>95015663</aid><ce:pii>0006-8993(95)01566-3</ce:pii><ce:doi>10.1016/0006-8993(95)01566-3</ce:doi><ce:copyright type="unknown" year="1996">Elsevier Science B.V. All rights reserved</ce:copyright></item-info><head><ce:dochead><ce:textfn>Research report</ce:textfn></ce:dochead><ce:title>Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice</ce:title><ce:author-group><ce:author><ce:given-name>Dean E.</ce:given-name><ce:surname>Dluzen</ce:surname><ce:cross-ref refid="cor1"><ce:sup loc="post">*</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:textfn>Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P.O. Box 95, Rootstown, OH 44272-0095, USA</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>*</ce:label><ce:text>Corresponding author. Fax: (1) (216) 325-2524.</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="12" month="12" year="1995"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). In the present report we examined whether the predominantly male gonadal steroid hormone, testosterone, would similarly modulate MPTP-induced neurotoxicity. Male C57/B1 mice were assigned to one of the following five treatment conditions: (1) Intact, (2) Orchidectomized, (3) Intact + MPTP, (4) Orchidectomized + Testosterone + MPTP and (5) Orchidectomized + MPTP. Corpus striatal and olfactory tubercle dopamine, DOP AC and norepinephrine concentrations were determined from the animals within each of the five treatment conditions. Orchidectomy alone failed to alter striatal dopamine and DOPAC concentrations, with levels obtained being similar to that of Intact animals. MPTP treatment significantly reduced striatal dopamine and DOPAC concentrations, regardless of hormonal condition of the animal. Similar results were obtained for olfactory tubercle determinations, with the exception that DOPAC levels from Orchidectomized mice were significantly greater than Intact males. No significant differences were obtained for norepinephrine within either brain area sampled. These results show that unlike estrogen, testosterone is devoid of any capacity to modulate nigrostriatal dopaminergic neurotoxicity resulting from MPTP. These findings may be related to the gender differences which exist in the prevalence of Parkinson's disease.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Corpus striatum</ce:text></ce:keyword><ce:keyword><ce:text>Olfactory tubercle</ce:text></ce:keyword><ce:keyword><ce:text>Parkinson's disease</ce:text></ce:keyword><ce:keyword><ce:text>Sex differences</ce:text></ce:keyword><ce:keyword><ce:text>Orchidectomy</ce:text></ce:keyword><ce:keyword><ce:text>Estrogen</ce:text></ce:keyword></ce:keywords></head><tail view="all"><ce:bibliography view="all" id="bibliography.0010"><ce:section-title>References</ce:section-title><ce:bibliography-sec id="bibliography-sec.0010"><ce:bib-reference id="bib1"><ce:label>[1]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bazzett</ce:surname><ce:given-name>T.J.</ce:given-name></sb:author><sb:author><ce:surname>Becker</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Sex differences in the rapid and acute effects of estrogen on striatal D<ce:inf loc="post">2</ce:inf> dopamine receptor binding</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>637</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>163</sb:first-page><sb:last-page>172</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>[2]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Beatty</ce:surname><ce:given-name>W.W.</ce:given-name></sb:author><sb:author><ce:surname>Dodge</ce:surname><ce:given-name>A.M.</ce:given-name></sb:author><sb:author><ce:surname>Traylor</ce:surname><ce:given-name>K.L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Stereotyped behavior elicited by amphetamine in the rat: influence of the testes</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pharm. Biochem. Behav.</sb:maintitle></sb:title><sb:volume-nr>16</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>565</sb:first-page><sb:last-page>568</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib3"><ce:label>[3]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Becker</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Direct effect of 17<ce:italic>β</ce:italic>-estradiol on striatum: Sex differ-ences in dopamine release</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Synapse</sb:maintitle></sb:title><sb:volume-nr>5</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>157</sb:first-page><sb:last-page>164</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib4"><ce:label>[4]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Becker</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author><sb:author><ce:surname>Beer</ce:surname><ce:given-name>M.E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The influence of estrogen on nigrostriatal dopamine activity: Behavioral and neurochemical evidence for both pre- and postsynaptic components</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Behav. Brain Res.</sb:maintitle></sb:title><sb:volume-nr>19</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>27</sb:first-page><sb:last-page>33</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib5"><ce:label>[5]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Becker</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author><sb:author><ce:surname>Cha</ce:surname><ce:given-name>J.-H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Estrous cycle dependent variations in amphetamine-induced behaviors and striatal dopamine release assessed with microdialysis</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Behav. Brain Res.</sb:maintitle></sb:title><sb:volume-nr>35</sb:volume-nr></sb:series><sb:date>1989</sb:date></sb:issue><sb:pages><sb:first-page>117</sb:first-page><sb:last-page>125</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib6"><ce:label>[6]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Becker</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author><sb:author><ce:surname>Robinson</ce:surname><ce:given-name>T.E.</ce:given-name></sb:author><sb:author><ce:surname>Lorenz</ce:surname><ce:given-name>K.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Sex differences and estrous cycle variations in amphetamine-elicited rotational behavior</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>eur. J. Pharm.</sb:maintitle></sb:title><sb:volume-nr>80</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>65</sb:first-page><sb:last-page>72</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib7"><ce:label>[7]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Becker</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author><sb:author><ce:surname>Synder</ce:surname><ce:given-name>P.J.</ce:given-name></sb:author><sb:author><ce:surname>Miller</ce:surname><ce:given-name>M.M.</ce:given-name></sb:author><sb:author><ce:surname>Westgate</ce:surname><ce:given-name>S.A.</ce:given-name></sb:author><sb:author><ce:surname>Jenuwine</ce:surname><ce:given-name>M.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The influence of estrous cycle and intrastriatal estradiol on sensorimotor performance in the female rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pharm. Biochem. Behav.</sb:maintitle></sb:title><sb:volume-nr>27</sb:volume-nr></sb:series><sb:date>1987</sb:date></sb:issue><sb:pages><sb:first-page>53</sb:first-page><sb:last-page>59</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib8"><ce:label>[8]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bedard</ce:surname><ce:given-name>P.J.</ce:given-name></sb:author><sb:author><ce:surname>Langelier</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Dankova</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Villeneuve</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Di Paolo</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Barden</ce:surname><ce:given-name>N.</ce:given-name></sb:author><sb:author><ce:surname>Labrie</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Boissier</ce:surname><ce:given-name>J.R.</ce:given-name></sb:author><sb:author><ce:surname>Euvard</ce:surname><ce:given-name>C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Estrogens progesterone and the extrapyramidal system</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Adv. Neurol.</sb:maintitle></sb:title><sb:volume-nr>24</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>411</sb:first-page><sb:last-page>422</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib9"><ce:label>[9]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bernard</ce:surname><ce:given-name>B.K.</ce:given-name></sb:author><sb:author><ce:surname>Paolino</ce:surname><ce:given-name>R.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Time dependent changes in brain biogenic amine dynamics following castration in male rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>22</sb:volume-nr></sb:series><sb:date>1974</sb:date></sb:issue><sb:pages><sb:first-page>951</sb:first-page><sb:last-page>956</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib10"><ce:label>[10]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bitar</ce:surname><ce:given-name>M.S.</ce:given-name></sb:author><sb:author><ce:surname>Ota</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Linnoila</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Shapiro</ce:surname><ce:given-name>B.H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Modification of gonadectomy-induced increases in brain monoamine metabolism by steroid hormones in male and female rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Psychoneuroen-docrinology</sb:maintitle></sb:title><sb:volume-nr>16</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>547</sb:first-page><sb:last-page>557</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib11"><ce:label>[11]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Camp</ce:surname><ce:given-name>D.M.</ce:given-name></sb:author><sb:author><ce:surname>Becker</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author><sb:author><ce:surname>Robinson</ce:surname><ce:given-name>T.E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Sex differences in the effects of gonadectomy on amphetamine-induced rotational be-havior in rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Behav. Neural Biol.</sb:maintitle></sb:title><sb:volume-nr>46</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>491</sb:first-page><sb:last-page>495</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib12"><ce:label>[12]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Chiodo</ce:surname><ce:given-name>L.A.</ce:given-name></sb:author><sb:author><ce:surname>Cagguila</ce:surname><ce:given-name>A.R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Substantia nigra dopamine neurons: Alterations in basal discharge rates and autoreceptor sensitivity induced by estrogen</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuropharmacology</sb:maintitle></sb:title><sb:volume-nr>22</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>593</sb:first-page><sb:last-page>599</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib13"><ce:label>[13]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Crowley</ce:surname><ce:given-name>W.R.</ce:given-name></sb:author><sb:author><ce:surname>O'Donohue</ce:surname><ce:given-name>T.L.</ce:given-name></sb:author><sb:author><ce:surname>Jacobowitz</ce:surname><ce:given-name>D.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Sex differences in the catecholamine content in discrete brain nuclei of the rat: Effects of neonatal castration or testosterone treatment</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Acta Endocrinol.</sb:maintitle></sb:title><sb:volume-nr>89</sb:volume-nr></sb:series><sb:date>1978</sb:date></sb:issue><sb:pages><sb:first-page>20</sb:first-page><sb:last-page>28</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib14"><ce:label>[14]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Diamond</ce:surname><ce:given-name>S.G.</ce:given-name></sb:author><sb:author><ce:surname>Markham</ce:surname><ce:given-name>C.H.</ce:given-name></sb:author><sb:author><ce:surname>Hoehn</ce:surname><ce:given-name>M.M.</ce:given-name></sb:author><sb:author><ce:surname>McDowell</ce:surname><ce:given-name>F.H.</ce:given-name></sb:author><sb:author><ce:surname>Muenter</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>An examination of male-female differences in progression and mortality of Parkinson's disease</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurology</sb:maintitle></sb:title><sb:volume-nr>40</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>763</sb:first-page><sb:last-page>766</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib15"><ce:label>[15]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Di Paolo</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Falardeau</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Morrisette</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Striatal D<ce:inf loc="post">2</ce:inf> dopamine agonist binding sites fluctuate during the rat estrous cycle</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Life Sci.</sb:maintitle></sb:title><sb:volume-nr>43</sb:volume-nr></sb:series><sb:date>1988</sb:date></sb:issue><sb:pages><sb:first-page>665</sb:first-page><sb:last-page>672</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib16"><ce:label>[16]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Dluzen</ce:surname><ce:given-name>D.E.</ce:given-name></sb:author><sb:author><ce:surname>Green</ce:surname><ce:given-name>M.A.</ce:given-name></sb:author><sb:author><ce:surname>Ramirez</ce:surname><ce:given-name>V.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The effect of hormonal condition on dose-dependent amphetamine-stimulated be-haviors in the male rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Horm. Behav.</sb:maintitle></sb:title><sb:volume-nr>20</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>1</sb:first-page><sb:last-page>6</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib17"><ce:label>[17]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Dluzen Jain</ce:surname><ce:given-name>R.</ce:given-name></sb:author><sb:author><ce:surname>Liu</ce:surname><ce:given-name>B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Modulatory effects of testosterone upon l-methyl-4-phenyl-1,2.3,6-tetrahydropyridine (MPTP) -induced neurotoxicity</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>62</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>94</sb:first-page><sb:last-page>101</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib18"><ce:label>[18]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Dluzen</ce:surname><ce:given-name>D.E.</ce:given-name></sb:author><sb:author><ce:surname>McDermott</ce:surname><ce:given-name>J.L.</ce:given-name></sb:author><sb:author><ce:surname>Liu</ce:surname><ce:given-name>B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Estrogen alters MPTP-induced neurotoxicity in female mice: Effects on striatal dopamine concentrations and release</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>66</sb:volume-nr></sb:series><sb:date>1996</sb:date></sb:issue><sb:pages><sb:first-page>658</sb:first-page><sb:last-page>666</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib19"><ce:label>[19]</ce:label><sb:reference><sb:comment>submitted.</sb:comment><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Dluzen</ce:surname><ce:given-name>D.E.</ce:given-name></sb:author><sb:author><ce:surname>McDermott</ce:surname><ce:given-name>J.L.</ce:given-name></sb:author><sb:author><ce:surname>Liu</ce:surname><ce:given-name>B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Estrogen as a neuroprotectant against MPTP-induced neurotoxicity in C57/B1 mice</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurosci. Lett.</sb:maintitle></sb:title></sb:series><sb:date>1996</sb:date></sb:issue></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib20"><ce:label>[20]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Dluzen</ce:surname><ce:given-name>D.E.</ce:given-name></sb:author><sb:author><ce:surname>Ramirez</ce:surname><ce:given-name>V.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>In vitro dopamine release from the rat striatum: Diurnal rhythm and its modification by the estrous cycle</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroendocrinology</sb:maintitle></sb:title><sb:volume-nr>41</sb:volume-nr></sb:series><sb:date>1985</sb:date></sb:issue><sb:pages><sb:first-page>97</sb:first-page><sb:last-page>100</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib21"><ce:label>[21]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Dluzen</ce:surname><ce:given-name>D.E.</ce:given-name></sb:author><sb:author><ce:surname>Ramirez</ce:surname><ce:given-name>V.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Effects of orchidectomy on nigro-striatal dopaminergic function: Behavioral and physiological evi-dence</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neuroendocrinol.</sb:maintitle></sb:title><sb:volume-nr>1</sb:volume-nr></sb:series><sb:date>1989</sb:date></sb:issue><sb:pages><sb:first-page>285</sb:first-page><sb:last-page>290</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib22"><ce:label>[22]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Dluzen</ce:surname><ce:given-name>D.E.</ce:given-name></sb:author><sb:author><ce:surname>Ramirez</ce:surname><ce:given-name>V.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>In vivo changes in responsiveness of the caudate nucleus to L-DOPA infusions as a function of the estrous cycle</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>536</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>163</sb:first-page><sb:last-page>168</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib23"><ce:label>[23]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Endersby</ce:surname><ce:given-name>C.A.</ce:given-name></sb:author><sb:author><ce:surname>Wilson</ce:surname><ce:given-name>C.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The effect of ovarian steroids on the accumulation of <ce:sup loc="post">3</ce:sup>H-labeled monoamines by hypothalamic tissue in vitro</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>73</sb:volume-nr></sb:series><sb:date>1974</sb:date></sb:issue><sb:pages><sb:first-page>321</sb:first-page><sb:last-page>331</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib24"><ce:label>[24]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Engel</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Ahlenius</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Almgren</ce:surname><ce:given-name>O.</ce:given-name></sb:author><sb:author><ce:surname>Carlsson</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Larsson</ce:surname><ce:given-name>K.</ce:given-name></sb:author><sb:author><ce:surname>Sodersten</ce:surname><ce:given-name>P.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Effects of gonadectomy and hormone replacement on brain monoamine synthesis in male rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pharm. Biochem. Behav.</sb:maintitle></sb:title><sb:volume-nr>10</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>149</sb:first-page><sb:last-page>154</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib25"><ce:label>[25]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Falardeau</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Di Paolo</ce:surname><ce:given-name>T.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Regional effect of estradiol on rat caudate-putamen dopamine receptors: lateral-medial differences</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurosci. Lett.</sb:maintitle></sb:title><sb:volume-nr>74</sb:volume-nr></sb:series><sb:date>1987</sb:date></sb:issue><sb:pages><sb:first-page>43</sb:first-page><sb:last-page>48</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib26"><ce:label>[26]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Fernandez-Ruiz</ce:surname><ce:given-name>J.J.</ce:given-name></sb:author><sb:author><ce:surname>Hernandez</ce:surname><ce:given-name>M.L.</ce:given-name></sb:author><sb:author><ce:surname>deMiguel</ce:surname><ce:given-name>R.</ce:given-name></sb:author><sb:author><ce:surname>Ramos</ce:surname><ce:given-name>J.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Nigrostriatal and mesolimbic dopaminergic activities were modified throughout the ovarian cycle of female rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neural Transm.</sb:maintitle></sb:title><sb:volume-nr>85</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>223</sb:first-page><sb:last-page>229</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib27"><ce:label>[27]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Gamboa</ce:surname><ce:given-name>E.T.</ce:given-name></sb:author><sb:author><ce:surname>Isaacs</ce:surname><ce:given-name>G.</ce:given-name></sb:author><sb:author><ce:surname>Harter</ce:surname><ce:given-name>D.H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Chorea associated with oral contraceptive therapy</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Arch. Neurol.</sb:maintitle></sb:title><sb:volume-nr>25</sb:volume-nr></sb:series><sb:date>1971</sb:date></sb:issue><sb:pages><sb:first-page>112</sb:first-page><sb:last-page>114</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib28"><ce:label>[28]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Glazer</ce:surname><ce:given-name>W.M.</ce:given-name></sb:author><sb:author><ce:surname>Naftolin</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Morgenstern</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Barnea</ce:surname><ce:given-name>E.R.</ce:given-name></sb:author><sb:author><ce:surname>MacLusky</ce:surname><ce:given-name>N.J.</ce:given-name></sb:author><sb:author><ce:surname>Brenner</ce:surname><ce:given-name>L.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Estrogen replacement and tardive dyskinesia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Psychoneuroendocrinology</sb:maintitle></sb:title><sb:volume-nr>10</sb:volume-nr></sb:series><sb:date>1985</sb:date></sb:issue><sb:pages><sb:first-page>345</sb:first-page><sb:last-page>350</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib29"><ce:label>[29]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Gordon</ce:surname><ce:given-name>J.H.</ce:given-name></sb:author><sb:author><ce:surname>Borison</ce:surname><ce:given-name>R.L.</ce:given-name></sb:author><sb:author><ce:surname>Diamond</ce:surname><ce:given-name>B.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Estrogen in experimental tardive dyskinesia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurology</sb:maintitle></sb:title><sb:volume-nr>30</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>551</sb:first-page><sb:last-page>554</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib30"><ce:label>[30]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Gupta</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Gupta</ce:surname><ce:given-name>B.K.</ce:given-name></sb:author><sb:author><ce:surname>Thomas</ce:surname><ce:given-name>R.</ce:given-name></sb:author><sb:author><ce:surname>Bruemmer</ce:surname><ce:given-name>V.</ce:given-name></sb:author><sb:author><ce:surname>Sladek</ce:surname><ce:given-name>J.R.</ce:given-name><ce:suffix>Jr.</ce:suffix></sb:author><sb:author><ce:surname>Felten</ce:surname><ce:given-name>D.L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Aged mice are more sensitive to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment than young adults</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurosci. Lett.</sb:maintitle></sb:title><sb:volume-nr>70</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>326</sb:first-page><sb:last-page>331</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib31"><ce:label>[31]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Hruska</ce:surname><ce:given-name>R.E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Elevation of striatal dopamine receptors by estrogen: Dose and time studies</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>47</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>1908</sb:first-page><sb:last-page>1915</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib32"><ce:label>[32]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Maus</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Premont</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Glowinski</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>In vitro effects of 17<ce:italic>β</ce:italic>-oestradiol on the sensitivity of receptors coupled to adenylate cy-clase on striatal neurons in primary culture</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:book-series><sb:series><sb:title><sb:maintitle>Ciba Found. Symp.</sb:maintitle></sb:title><sb:volume-nr>153</sb:volume-nr></sb:series></sb:book-series><sb:date>1990</sb:date></sb:edited-book><sb:pages><sb:first-page>145</sb:first-page><sb:last-page>155</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib33"><ce:label>[33]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>McDermott</ce:surname><ce:given-name>J.L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Effects of estrogen upon dopamine release from the corpus striatum of young and aged female rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>606</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>118</sb:first-page><sb:last-page>125</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib34"><ce:label>[34]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>McDermott</ce:surname><ce:given-name>J.L.</ce:given-name></sb:author><sb:author><ce:surname>Liu</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Dluzen</ce:surname><ce:given-name>D.E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Sex differences and effects of estrogen on dopamine and DOPAC release from the corpus striatum of male and female CD-1 mice</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Exp. Neurol.</sb:maintitle></sb:title><sb:volume-nr>125</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>306</sb:first-page><sb:last-page>311</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib35"><ce:label>[35]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>McDermott</ce:surname><ce:given-name>J.L.</ce:given-name></sb:author><sb:author><ce:surname>Kreutzberg</ce:surname><ce:given-name>J.D.</ce:given-name></sb:author><sb:author><ce:surname>Liu</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Dluzen</ce:surname><ce:given-name>D.E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Effects of estrogen treatment on sensorimotor task performance and brain dopamine concentrations in gonadectomized male and female CD-1 mice</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Horm. Behav.</sb:maintitle></sb:title><sb:volume-nr>28</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>16</sb:first-page><sb:last-page>28</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib36"><ce:label>[36]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Menniti</ce:surname><ce:given-name>F.S.</ce:given-name></sb:author><sb:author><ce:surname>Baum</ce:surname><ce:given-name>M.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Differential effects of estrogen and androgen on locomotor activity induced in castrated rats by am-phetamine, a novel environment or apomorphine</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>216</sb:volume-nr></sb:series><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>89</sb:first-page><sb:last-page>107</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib37"><ce:label>[37]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Michel</ce:surname><ce:given-name>M.C.</ce:given-name></sb:author><sb:author><ce:surname>Roth</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Hiemke</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Ghraf</ce:surname><ce:given-name>R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Inhibition of synaptosomal high affinity uptake of dopamine and serotonin by estrogen agonists and antagonists</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Biochem. Pharm.</sb:maintitle></sb:title><sb:volume-nr>36</sb:volume-nr></sb:series><sb:date>1987</sb:date></sb:issue><sb:pages><sb:first-page>3175</sb:first-page><sb:last-page>3180</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib38"><ce:label>[38]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Mitchell</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author><sb:author><ce:surname>Stewart</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Effects of castration, steroid replacement and sexual experience on mesolimbic dopamine and sexual behaviors in the male rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>491</sb:volume-nr></sb:series><sb:date>1989</sb:date></sb:issue><sb:pages><sb:first-page>116</sb:first-page><sb:last-page>127</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib39"><ce:label>[39]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Morrisette</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Garcia-Segura</ce:surname><ce:given-name>L.-M.</ce:given-name></sb:author><sb:author><ce:surname>Belanger</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Di Paolo</ce:surname><ce:given-name>T.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Changes of rat striatal neuronal membrane morphology and steroid content during the estrous cycle</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>49</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>893</sb:first-page><sb:last-page>902</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib40"><ce:label>[40]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Nausieda</ce:surname><ce:given-name>P.A.</ce:given-name></sb:author><sb:author><ce:surname>Koller</ce:surname><ce:given-name>W.C.</ce:given-name></sb:author><sb:author><ce:surname>Weiner</ce:surname><ce:given-name>W.J.</ce:given-name></sb:author><sb:author><ce:surname>Klawans</ce:surname><ce:given-name>H.L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Chorea induced by oral contraceptives</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurology</sb:maintitle></sb:title><sb:volume-nr>29</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>1605</sb:first-page><sb:last-page>1609</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib41"><ce:label>[41]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Ramirez</ce:surname><ce:given-name>V.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Hormones and striatal dopaminergic activity: a novel neuroendocrine model</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:given-name>A.S.</ce:given-name><ce:surname>Bhatnagar</ce:surname></sb:editor></sb:editors><sb:title><sb:maintitle>The Anterior Pituitary Gland</sb:maintitle></sb:title><sb:date>1983</sb:date><sb:publisher><sb:name>Raven Press</sb:name></sb:publisher></sb:edited-book><sb:pages><sb:first-page>97</sb:first-page><sb:last-page>105</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib42"><ce:label>[42]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Savageau</ce:surname><ce:given-name>M.M.</ce:given-name></sb:author><sb:author><ce:surname>Beatty</ce:surname><ce:given-name>W.W.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Gonadectomy and sex differ-ences in the behavioral responses to amphetamine and apomorphine of rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pharm. Biochem. Behav.</sb:maintitle></sb:title><sb:volume-nr>14</sb:volume-nr></sb:series><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>17</sb:first-page><sb:last-page>22</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib43"><ce:label>[43]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Tansey</ce:surname><ce:given-name>E.M.</ce:given-name></sb:author><sb:author><ce:surname>Arbuthnott</ce:surname><ce:given-name>G.W.</ce:given-name></sb:author><sb:author><ce:surname>Fink</ce:surname><ce:given-name>G.</ce:given-name></sb:author><sb:author><ce:surname>Whale</ce:surname><ce:given-name>D</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Oestra-diol-17<ce:italic>β</ce:italic> increases the firing rate of antidromically identified neu-rons of the rat neostriatum</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroendocrinology</sb:maintitle></sb:title><sb:volume-nr>37</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>106</sb:first-page><sb:last-page>110</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib44"><ce:label>[44]</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>van Hartesveldt</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Joyce</ce:surname><ce:given-name>J.N.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Effect of estrogen on the basal ganglia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurosci. Biobehav. Rev.</sb:maintitle></sb:title><sb:volume-nr>10</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>1</sb:first-page><sb:last-page>14</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice</title></titleInfo><name type="personal"><namePart type="given">Dean E.</namePart><namePart type="family">Dluzen</namePart><affiliation>Department of Anatomy, Northeastern Ohio Universities College of Medicine, 4209 State Route 44, P.O. Box 95, Rootstown, OH 44272-0095, USA</affiliation><description>Corresponding author. Fax: (1) (216) 325-2524.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><dateValid encoding="w3cdtf">1995-12-12</dateValid><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP). In the present report we examined whether the predominantly male gonadal steroid hormone, testosterone, would similarly modulate MPTP-induced neurotoxicity. Male C57/B1 mice were assigned to one of the following five treatment conditions: (1) Intact, (2) Orchidectomized, (3) Intact + MPTP, (4) Orchidectomized + Testosterone + MPTP and (5) Orchidectomized + MPTP. Corpus striatal and olfactory tubercle dopamine, DOP AC and norepinephrine concentrations were determined from the animals within each of the five treatment conditions. Orchidectomy alone failed to alter striatal dopamine and DOPAC concentrations, with levels obtained being similar to that of Intact animals. MPTP treatment significantly reduced striatal dopamine and DOPAC concentrations, regardless of hormonal condition of the animal. Similar results were obtained for olfactory tubercle determinations, with the exception that DOPAC levels from Orchidectomized mice were significantly greater than Intact males. No significant differences were obtained for norepinephrine within either brain area sampled. These results show that unlike estrogen, testosterone is devoid of any capacity to modulate nigrostriatal dopaminergic neurotoxicity resulting from MPTP. These findings may be related to the gender differences which exist in the prevalence of Parkinson's disease.</abstract><note type="content">Section title: Research report</note><subject lang="en"><genre>Keywords</genre><topic>Corpus striatum</topic><topic>Olfactory tubercle</topic><topic>Parkinson's disease</topic><topic>Sex differences</topic><topic>Orchidectomy</topic><topic>Estrogen</topic></subject><relatedItem type="host"><titleInfo><title>Brain Research</title></titleInfo><titleInfo type="abbreviated"><title>BRES</title></titleInfo><genre type="Journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19960409</dateIssued></originInfo><identifier type="ISSN">0006-8993</identifier><identifier type="PII">S0006-8993(00)X1716-7</identifier><part><date>19960409</date><detail type="volume"><number>715</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>234</end></extent><extent unit="pages"><start>113</start><end>118</end></extent></part></relatedItem><identifier type="istex">283969BD863F7C1F733916479DA0E5850489CDA3</identifier><identifier type="DOI">10.1016/0006-8993(95)01566-3</identifier><identifier type="PII">0006-8993(95)01566-3</identifier><identifier type="ArticleID">95015663</identifier><accessCondition type="use and reproduction" contentType="">© 1996Elsevier Science B.V. 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